Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk.

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Version: author
Serval ID
serval:BIB_FB39146F35F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk.
Journal
AIDS research and human retroviruses
Author(s)
Obuku A.E., Asiki G., Abaasa A., Ssonko I., Harari A., van Dam G.J., Corstjens P.L., Joloba M., Ding S., Mpendo J., Nielsen L., Kamali A., Elliott A.M., Pantaleo G., Kaleebu P., Pala P.
ISSN
1931-8405 (Electronic)
ISSN-L
0889-2229
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
32
Number
7
Pages
668-675
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
In Uganda, fisher folk have HIV prevalence rates, about four times higher than the national average, and are often coinfected with Schistosoma mansoni. We hypothesized that innate immune responses and HIV-specific Th1 immune responses might be downmodulated in HIV/S. mansoni-coinfected individuals compared with HIV+/S. mansoni-negative individuals. We stimulated whole blood with innate receptor agonists and analyzed supernatant cytokines by Luminex. We evaluated HIV-specific responses by intracellular cytokine staining for IFN-γ, IL-2, and TNF-α. We found that the plasma viral load and CD4 count were similar between the HIV+SM+ and HIV+SM- individuals. In addition, the TNF-α response to the imidazoquinoline compound CL097 and β-1, 3-glucan (curdlan), was significantly higher in HIV/S. mansoni-coinfected individuals compared with HIV only-infected individuals. The frequency of HIV-specific IFN-γ+IL-2-TNF-α- CD8 T cells and IFN-γ+IL-2-TNF-α+ CD4 T cells was significantly higher in HIV/S. mansoni-coinfected individuals compared with HIV only-infected individuals. These findings do not support the hypothesis that S. mansoni downmodulates innate or HIV-specific Th1 responses in HIV/S. mansoni-coinfected individuals.

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20/02/2016 17:11
Last modification date
20/08/2019 16:26
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