HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.

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Ressource 1Download: BIB_F78CF6A3B249.P001.pdf (915.19 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_F78CF6A3B249
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1.
Journal
Plos Pathogens
Author(s)
Izquierdo-Useros N., Lorizate M., McLaren P.J., Telenti A., Kräusslich H.G., Martinez-Picado J.
ISSN
1553-7374 (Electronic)
ISSN-L
1553-7366
Publication state
Published
Issued date
2014
Volume
10
Number
7
Pages
e1004146
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: epublish Document Type: Review, pdf: Review
Abstract
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans-infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans-infection.
Pubmed
Web of science
Open Access
Yes
Create date
19/09/2014 17:13
Last modification date
20/08/2019 16:23
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