The dysfunction of T follicular helper cells.

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State: Public
Version: author
Serval ID
serval:BIB_F7472C604B41
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The dysfunction of T follicular helper cells.
Journal
Current Opinion In Hiv and Aids
Author(s)
Cubas R., Perreau M.
ISSN
1746-6318 (Electronic)
ISSN-L
1746-630X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
9
Number
5
Pages
485-491
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish Document Type: Review
Abstract
PURPOSE OF REVIEW: T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and how their functional changes might affect antibody responses.
RECENT FINDINGS: Recent studies have shown that HIV/simian immunodeficiency virus (SIV) infection affects both Tfh-cell frequency and function and suggest that Tfh-cell perturbations might contribute to the relative inefficiency of HIV-infected individuals to generate broadly neutralizing antibodies (bNAbs).
SUMMARY: The present review will highlight these recent findings addressing the role of Tfh cells in HIV infection as well as the impact HIV infection has on Tfh and circulating memory Tfh (cTfh) cell frequency and function.
Pubmed
Web of science
Create date
19/09/2014 17:41
Last modification date
20/08/2019 16:23
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