Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactis CNCM I-3446.

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Serval ID
serval:BIB_EE3F587B3B27
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Gut microbiota analysis reveals a marked shift to bifidobacteria by a starter infant formula containing a synbiotic of bovine milk-derived oligosaccharides and Bifidobacterium animalis subsp. lactis CNCM I-3446.
Journal
Environmental microbiology
Author(s)
Simeoni U., Berger B., Junick J., Blaut M., Pecquet S., Rezzonico E., Grathwohl D., Sprenger N., Brüssow H., Szajewska H., Bartoli J.M., Brevaut-Malaty V., Borszewska-Kornacka M., Feleszko W., François P., Gire C., Leclaire M., Maurin J.M., Schmidt S., Skórka A., Squizzaro C., Verdot J.J.
Working group(s)
Study Team
ISSN
1462-2920 (Electronic)
ISSN-L
1462-2912
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
18
Number
7
Pages
2185-2195
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
Non-digestible milk oligosaccharides were proposed as receptor decoys for pathogens and as nutrients for beneficial gut commensals like bifidobacteria. Bovine milk contains oligosaccharides, some of which are structurally identical or similar to those found in human milk. In a controlled, randomized double-blinded clinical trial we tested the effect of feeding a formula supplemented with a mixture of bovine milk-derived oligosaccharides (BMOS) generated from whey permeate, containing galacto-oligosaccharides and 3'- and 6'-sialyllactose, and the probiotic Bifidobacterium animalis subsp. lactis (B. lactis) strain CNCM I-3446. Breastfed infants served as reference group. Compared with a non-supplemented control formula, the test formula showed a similar tolerability and supported a similar growth in healthy newborns followed for 12 weeks. The control, but not the test group, differed from the breast-fed reference group by a higher faecal pH and a significantly higher diversity of the faecal microbiota. In the test group the probiotic B. lactis increased by 100-fold in the stool and was detected in all supplemented infants. BMOS stimulated a marked shift to a bifidobacterium-dominated faecal microbiota via increases in endogenous bifidobacteria (B. longum, B. breve, B. bifidum, B. pseudocatenulatum).

Keywords
Animals, Bacteria/classification, Bacteria/genetics, Bacteria/growth & development, Bacteria/isolation & purification, Bifidobacterium animalis/genetics, Bifidobacterium animalis/growth & development, Bifidobacterium animalis/isolation & purification, Bifidobacterium animalis/metabolism, Cattle, Feces/microbiology, Female, Food Additives/analysis, Food Additives/metabolism, Gastrointestinal Microbiome, Humans, Infant, Infant Formula/analysis, Infant, Newborn, Male, Milk/chemistry, Milk/metabolism, Oligosaccharides/analysis, Oligosaccharides/metabolism, Synbiotics/analysis
Pubmed
Web of science
Open Access
Yes
Create date
02/09/2016 15:11
Last modification date
20/08/2019 16:15
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