Neuronal inputs and outputs of aging and longevity.

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Serval ID
serval:BIB_ED3F11539783
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neuronal inputs and outputs of aging and longevity.
Journal
Frontiers in Genetics
Author(s)
Alcedo J., Flatt T., Pasyukova E.G.
ISSN
1664-8021 (Electronic)
ISSN-L
1664-8021
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
4
Pages
71
Language
english
Abstract
An animal's survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system. Here we highlight different aspects of the neuronal inputs and outputs of pathways that affect aging and longevity. Accordingly, we discuss how sensory inputs influence homeostasis and lifespan through the modulation of different types of neuronal signals, which reflects the complexity of the environmental cues that affect physiology. We also describe feedback, compensatory, and feed-forward mechanisms in these longevity-modulating pathways that are necessary for homeostasis. Finally, we consider the temporal requirements for these neuronal processes and the potential role of natural genetic variation in shaping the neurobiology of aging.
Keywords
aging, brain, homeostasis, longevity, nervous system, neuroendocrine system
Pubmed
Open Access
Yes
Create date
19/04/2013 15:26
Last modification date
20/08/2019 16:15
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