Circulating microRNAs as novel biomarkers for diabetes mellitus.

Details

Ressource 1Download: BIB_EC5DDF53FF36.P001.pdf (854.87 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_EC5DDF53FF36
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Circulating microRNAs as novel biomarkers for diabetes mellitus.
Journal
Nature Reviews. Endocrinology
Author(s)
Guay C., Regazzi R.
ISSN
1759-5037 (Electronic)
ISSN-L
1759-5029
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
9
Number
9
Pages
513-521
Language
english
Abstract
Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, patients with diabetes mellitus develop serious complications that reduce their quality of life and life expectancy. Biomarkers for early detection of the disease and identification of individuals at risk of developing complications would greatly improve the care of these patients. Small non-coding RNAs called microRNAs (miRNAs) control gene expression and participate in many physiopathological processes. Hundreds of miRNAs are actively or passively released in the circulation and can be used to evaluate health status and disease progression. Both type 1 diabetes mellitus and type 2 diabetes mellitus are associated with distinct modifications in the profile of miRNAs in the blood, which are sometimes detectable several years before the disease manifests. Moreover, circulating levels of certain miRNAs seem to be predictive of long-term complications. Technical and scientific obstacles still exist that need to be overcome, but circulating miRNAs might soon become part of the diagnostic arsenal to identify individuals at risk of developing diabetes mellitus and its devastating complications.
Pubmed
Web of science
Open Access
Yes
Create date
20/12/2013 11:43
Last modification date
20/08/2019 16:14
Usage data