Discovery and functional characterization of cardiovascular long noncoding RNAs

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State: Public
Version: Final published version
Serval ID
serval:BIB_EA12F2EC3C34
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Discovery and functional characterization of cardiovascular long noncoding RNAs
Journal
Journal of Molecular and Cellular Cardiology
Author(s)
Ounzain S., Burdet F., Ibberson M., Pedrazzini T.
ISSN
1095-8584 (Electronic)
ISSN-L
0022-2828
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
89
Number
Pt A
Pages
17-26
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Recent advances in sequencing and genomic technologies have resulted in the discovery of thousands of previously unannotated long noncoding RNAs (lncRNAs). However, their function in the cardiovascular system remains elusive. Here we review and discuss considerations for cardiovascular lncRNA discovery, annotation and functional characterization. Although we primarily focus on the heart, the proposed pipeline should foster functional and mechanistic exploration of these transcripts in various cardiovascular pathologies. Moreover, these insights could ultimately lead to novel therapeutic approaches targeting lncRNAs for the amelioration of cardiovascular diseases including heart failure.
Keywords
Cardiovascular System/metabolism, RNA, Long Noncoding/genetics, RNA, Long Noncoding/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
11/10/2016 15:30
Last modification date
20/08/2019 16:12
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