Rhea-a manually curated resource of biochemical reactions.

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State: Public
Version: Final published version
Serval ID
serval:BIB_E9A04015506E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rhea-a manually curated resource of biochemical reactions.
Journal
Nucleic Acids Research
Author(s)
Alcántara R., Axelsen K.B., Morgat A., Belda E., Coudert E., Bridge A., Cao H., de Matos P., Ennis M., Turner S., Owen G., Bougueleret L., Xenarios I., Steinbeck C.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
2012
Volume
40
Number
Database issue
Pages
D754-D760
Language
english
Abstract
Rhea (http://www.ebi.ac.uk/rhea) is a comprehensive resource of expert-curated biochemical reactions. Rhea provides a non-redundant set of chemical transformations for use in a broad spectrum of applications, including metabolic network reconstruction and pathway inference. Rhea includes enzyme-catalyzed reactions (covering the IUBMB Enzyme Nomenclature list), transport reactions and spontaneously occurring reactions. Rhea reactions are described using chemical species from the Chemical Entities of Biological Interest ontology (ChEBI) and are stoichiometrically balanced for mass and charge. They are extensively manually curated with links to source literature and other public resources on metabolism including enzyme and pathway databases. This cross-referencing facilitates the mapping and reconciliation of common reactions and compounds between distinct resources, which is a common first step in the reconstruction of genome scale metabolic networks and models.
Keywords
Biochemical Processes, Databases, Factual, Enzymes/metabolism, Internet, Metabolic Networks and Pathways, Software
Pubmed
Web of science
Open Access
Yes
Create date
17/10/2012 10:30
Last modification date
20/08/2019 16:12
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