Host genetics and HIV-1: the final phase?

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Serval ID
serval:BIB_E67B8A43EB37
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Host genetics and HIV-1: the final phase?
Journal
Plos Pathogens
Author(s)
Fellay J., Shianna K.V., Telenti A., Goldstein D.B.
ISSN
1553-7374[electronic], 1553-7366[linking]
Publication state
Published
Issued date
2010
Volume
6
Number
10
Pages
e1001033
Language
english
Abstract
This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.
Pubmed
Web of science
Open Access
Yes
Create date
14/12/2010 9:23
Last modification date
20/08/2019 16:09
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