Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions.
Details
Serval ID
serval:BIB_E611B0AC7C4C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Performance of the PEdiatric Logistic Organ Dysfunction-2 score in critically ill children requiring plasma transfusions.
Journal
Annals of intensive care
Working group(s)
PlasmaTV investigators
Contributor(s)
Butt W., Delzoppo C., Bain K., Erickson S., Smalley N., Dorofaeff T., Long D., Wiseman G., Clénent de Cléty S., Berghe C., de Jaeger A., Demaret P., Trippaerts M., Willems A., Rooze S., De Dooy J., Gilfoyle E., Wohlgemuth L., Tucci M., Dumitrascu M., Withington D., Hickey J., Choong K., Sanders L., Morrison G., Tijssen J., Wensley D., Krahn G., Dugas M.A., Gosselin L., Santschi M., Von Dessauer B., Ordenes N., Afshari A., Andersen L.H., Nilsson J.C., Johansen M., Baek Jensen A.M., Campos Mino S., Grunauer M., Joram N., Roullet-Renoleau N., Javouhey E., Cour-Andlauer F., Portefaix A., Brissaud O., Guichoux J., Payen V., Léger P.L., Afanetti M., Mortamet G., Maria M., Breining A., Tissieres P., Dorkenoo A., Deho A., Steinherr H., Nikolaou F., Camporesi A., Mario F., Kawasaki T., Miura S., Beca J., Rea M., Sherring C., Bushell T., Bentsen G., Dinis A., Pereira G., Vieira M., Moniz M., Alshehri S., Alasnag M., Pisarcikova M., Jordan I., Balcells J., Perez-Ferrer A., de Vicente Sánchez J., Vazquez Moyano M., Morales Martinez A., Lopez-Herce J., Solana M.J., Flores González J.C., Alonso M.T., Nieto Faza M., Perez M.H., Amiet V., Doell C., Bordessoule A., Cochius-den Otter S., Kapitein B., Kneyber M., Brierley J., Rea V., McKeever S., Kelleher A., Scholefield B., Top A., Kelly N., Virdee S., Davis P., George S., Hawkins K.C., McCall K., Brown V., Sykes K., Levin R., MacLeod I., Horan M., Jirasek P., Inwald D., Abdulla A., Raghunanan S., Taylor B., Shefler A., Sparkes H., Hanson S., Woods K., Triscari D., Murkowski K., Ozment C., Steiner M., Nerheim D., Galster A., Higgerson R., Christie L., Spinella P.C., Martin D., Rourke L., Muszynski J., Steele L., Ajizian S., McCrory M.C., O'Brien K., Babbitt C., Felkel E., Levine G., Truemper E.J., Zink M., Nellis M., Thomas N.J., Spear D., Markovitz B., Terry J., Morzov R., Montgomery V., Michael A., Thomas M., Singleton M., Jarvis D., Nett S., Willson D., Hoot M., Bembea M., Yiu A., McKinley D., Scarlett E., Sankey J., Parikh M., Faustino EVS, Michelson K., Rilinger J., Campbell L., Gertz S., Cholette J.M., Jeyapalan A., Parker M., Bateman S., Johnson A.
ISSN
2110-5820 (Print)
ISSN-L
2110-5820
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
6
Number
1
Pages
98
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions.
This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer-Lemeshow test).
Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71-0.81) and the Hosmer-Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1.
In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
This was an ancillary study of a prospective observational study on plasma transfusions over a 6-week period, in 101 PICUs in 21 countries. All critically ill children who received at least one plasma transfusion during the observation period were included. PELOD-2 scores were measured on days 1, 2, 5, 8, and 12 after plasma transfusion. Performance of the score was assessed by the determination of the discrimination (area under the ROC curve: AUC) and the calibration (Hosmer-Lemeshow test).
Four hundred and forty-three patients were enrolled in the study (median age and weight: 1 year and 9.1 kg, respectively). Observed mortality rate was 26.9 % (119/443). For PELOD-2 on day 1, the AUC was 0.76 (95 % CI 0.71-0.81) and the Hosmer-Lemeshow test was p = 0.76. The serial evaluation of the changes in the daily PELOD-2 scores from day 1 demonstrated a significant association with death, adjusted for the PELOD-2 score on day 1.
In a subpopulation of critically ill children requiring plasma transfusion, the PELOD-2 score has a lower but acceptable discrimination than in an entire population. This score should therefore be used cautiously in this specific subpopulation.
Keywords
Children, Critical care, Multiple organ failure, Outcome, Plasma transfusion, Score
Pubmed
Web of science
Open Access
Yes
Create date
01/05/2018 9:22
Last modification date
20/08/2019 17:09
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