PPARgamma expression in normal human placenta, hydatidiform mole and choriocarcinoma

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Serval ID
serval:BIB_E3DAB0862B8B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
PPARgamma expression in normal human placenta, hydatidiform mole and choriocarcinoma
Journal
Molecular Human Reproduction
Author(s)
Capparuccia  L., Marzioni  D., Giordano  A., Fazioli  F., De Nictolis  M., Busso  N., Todros  T., Castellucci  M.
ISSN
1360-9947 (Print)
Publication state
Published
Issued date
06/2002
Volume
8
Number
6
Pages
574-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
Peroxisome proliferator-activated receptor (PPAR) gamma belongs to a subclass of nuclear hormone receptors that execute their transcriptional functions as heterodimers with the retinoid X receptors (RXR). PPARgamma plays a pivotal role in cellular differentiation. This study investigated PPARgamma protein expression in normal human placentas, hydatidiform moles and choriocarcinoma, using immunohistochemical and Western blot analyses. In first trimester normal placenta, PPARgamma was mainly localized in the nuclei of the villous cytotrophoblastic cells, whereas at term it was mainly localized in the nuclei of the syncytiotrophoblast. Extravillous cytotrophoblast of cell islands and cell columns also showed nuclear PPARgamma immunostaining. A striking result was the altered expression patterns of PPARgamma in pathological tissues; PPARgamma showed a reduced immunostaining in the trophoblastic diseases. In hydatidiform moles, PPARgamma was mainly localized in the nuclei of the trophoblastic collections of the pathological villi and in the extravillous trophoblastic cells, whereas in the choriocarcinoma, only a few trophoblastic cells showed weak PPARgamma nuclear immunostaining. These findings suggest an involvement of PPARgamma in trophoblast differentiation during normal placental development. The down-regulation of PPARgamma expression in the gestational trophoblastic diseases analysed in this study provides a new insight into the progression of these pathologies.
Keywords
Choriocarcinoma/*metabolism/pathology DNA-Binding Proteins/genetics/metabolism Female Humans Hydatidiform Mole/*metabolism/pathology Nuclear Proteins/genetics/metabolism Placenta/cytology/growth & development/*metabolism Pregnancy Pregnancy Trimesters Receptors, Cytoplasmic and Nuclear/genetics/*metabolism Transcription Factors/genetics/*metabolism Uterine Neoplasms/*metabolism/pathology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 8:29
Last modification date
14/02/2022 7:57
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