In this thesis, we develop tools to study the influence of predictors on multivariate distributions. We tackle the issue of conditional dependence modeling using generalized additive models, a natural extension of linear and generalized linear models allowing for smooth functions of the covariates. Compared to existing methods, the framework that we develop has two main advantages. First, it is completely flexible, in the sense that the dependence structure can vary with an arbitrary set of covariates in a parametric, nonparametric or semiparametric way. Second, it is both quick and numerically stable, which means that it is suitable for exploratory data analysis and stepwise model building. Starting from the bivariate case, we extend our framework to pair-copula constructions, and open new possibilities for further applied and methodological work. Our regression-like theory of the dependence, being built on conditional copulas and generalized additive models, is at the same time theoretically sound and practically useful.