Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E13FCF74BB37
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals.
Journal
Scientific reports
Author(s)
Liu C.T., Merino J., Rybin D., DiCorpo D., Benke K.S., Bragg-Gresham J.L., Canouil M., Corre T., Grallert H., Isaacs A., Kutalik Z., Lahti J., Marullo L., Marzi C., Rasmussen-Torvik L.J., Rocheleau G., Rueedi R., Scapoli C., Verweij N., Vogelzangs N., Willems S.M., Yengo L., Bakker SJL, Beilby J., Hui J., Kajantie E., Müller-Nurasyid M., Rathmann W., Balkau B., Bergmann S., Eriksson J.G., Florez J.C., Froguel P., Harris T., Hung J., James A.L., Kavousi M., Miljkovic I., Musk A.W., Palmer L.J., Peters A., Roussel R., van der Harst P., van Duijn C.M., Vollenweider P., Barroso I., Prokopenko I., Dupuis J., Meigs J.B., Bouatia-Naji N.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
01/07/2019
Peer-reviewed
Oui
Volume
9
Number
1
Pages
9439
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development of T2D. Here we conducted a genome-wide association study of longitudinal fasting glucose changes in up to 13,807 non-diabetic individuals of European descent from nine cohorts. Fasting glucose change over time was defined as the slope of the line defined by multiple fasting glucose measurements obtained over up to 14 years of observation. We tested for associations of genetic variants with inverse-normal transformed fasting glucose change over time adjusting for age at baseline, sex, and principal components of genetic variation. We found no genome-wide significant association (P < 5 × 10 <sup>-8</sup> ) with fasting glucose change over time. Seven loci previously associated with T2D, fasting glucose or HbA1c were nominally (P < 0.05) associated with fasting glucose change over time. Limited power influences unambiguous interpretation, but these data suggest that genetic effects on fasting glucose change over time are likely to be small. A public version of the data provides a genomic resource to combine with future studies to evaluate shared genetic links with T2D and other metabolic risk traits.
Pubmed
Web of science
Open Access
Yes
Create date
12/07/2019 16:01
Last modification date
21/11/2022 9:26
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