Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains.

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Serval ID
serval:BIB_D835D632579F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains.
Journal
Vaccine
Author(s)
Westdijk J., Koedam P., Barro M., Steil B.P., Collin N., Vedvick T.S., Bakker W.A., van der Ley P., Kersten G.
ISSN
1873-2518 (Electronic)
ISSN-L
0264-410X
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
31
Number
9
Pages
1298-1304
Language
english
Abstract
Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants.
Keywords
Sabin IPV, Oil-in water, PagL, AlOH3, Replicon particles, MPL
Pubmed
Web of science
Open Access
Yes
Create date
21/03/2013 8:24
Last modification date
20/08/2019 15:57
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