The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_D4BCA71B0F2E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis.
Journal
Trends in Parasitology
Author(s)
Hartley M.A., Drexler S., Ronet C., Beverley S.M., Fasel N.
ISSN
1471-5007 (Electronic)
ISSN-L
1471-4922
Publication state
Published
Issued date
2014
Volume
30
Number
8
Pages
412-422
Language
english
Abstract
Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic infections affecting millions of people across the subtropics. Symptoms range from the more prevalent single, self-healing cutaneous lesion to a persistent, metastatic disease, where ulcerations and granulomatous nodules can affect multiple secondary sites of the skin and delicate facial mucosa, even sometimes diffusing throughout the cutaneous system as a papular rash. The basis for such diverse pathologies is multifactorial, ranging from parasite phylogeny to host immunocompetence and various environmental factors. Although complex, these pathologies often prey on weaknesses in the innate immune system and its pattern recognition receptors. This review explores the observed and potential associations among the multifactorial perpetrators of infectious metastasis and components of the innate immune system.
Keywords
cutaneous leishmaniasis, metastatic leislunaniasis, post-kala-azar dermal leislunaniasis, Leishmania RNA virus, pattern recognition receptor, Toll-like receptor
Pubmed
Web of science
Open Access
Yes
Create date
04/09/2014 8:28
Last modification date
20/08/2019 15:54
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