Integrating nuclear receptor mobility in models of gene regulation.

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Serval ID
serval:BIB_D4A7B68B53C5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
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Publications
Institution
Title
Integrating nuclear receptor mobility in models of gene regulation.
Journal
Nuclear Receptor Signaling
Author(s)
Gelman L., Feige J.N., Tudor C., Engelborghs Y., Wahli W., Desvergne B.
ISSN
1550-7629[electronic]
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
4
Pages
e010
Language
english
Abstract
The mode of action of nuclear receptors in living cells is an actively investigated field but much remains hypothetical due to the lack, until recently, of methods allowing the assessment of molecular mechanisms in vivo. However, these last years, the development of fluorescence microscopy methods has allowed initiating the dissection of the molecular mechanisms underlying gene regulation by nuclear receptors directly in living cells or organisms. Following our analyses on peroxisome proliferator activated receptors (PPARs) in living cells, we discuss here the different models arising from the use of these tools, that attempt to link mobility, DNA binding or chromatin interaction, and transcriptional activity.
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24/01/2008 15:27
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20/08/2019 15:54
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