The α1-adrenergic receptors: diversity of signaling networks and regulation.

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Serval ID
serval:BIB_D04C2124AC80
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The α1-adrenergic receptors: diversity of signaling networks and regulation.
Journal
Journal of Receptor and Signal Transduction Research
Author(s)
Cotecchia S.
ISSN
1532-4281 (Electronic)
ISSN-L
1079-9893
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
30
Number
6
Pages
410-419
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
The α(1)-adrenergic receptor (AR) subtypes (α(1a), α(1b), and α(1d)) mediate several physiological effects of epinephrine and norepinephrine. Despite several studies in recombinant systems and insight from genetically modified mice, our understanding of the physiological relevance and specificity of the α(1)-AR subtypes is still limited. Constitutive activity and receptor oligomerization have emerged as potential features regulating receptor function. Another recent paradigm is that β arrestins and G protein-coupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. The aim of this review is to summarize our current knowledge on some recently identified functional paradigms and signaling networks that might help to elucidate the functional diversity of the α(1)-AR subtypes in various organs.
Keywords
Animals, Animals, Genetically Modified, Arrestins/metabolism, Epinephrine/metabolism, Norepinephrine/metabolism, Protein Isoforms/genetics, Protein Isoforms/metabolism, Receptors, Adrenergic, alpha-1/genetics, Receptors, Adrenergic, alpha-1/metabolism, Signal Transduction/physiology
Pubmed
Web of science
Create date
11/03/2011 17:53
Last modification date
20/10/2020 14:41
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