Evaluation of prenatal diagnosis of congenital heart disease in a regional controlled case study.

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Version: Final published version
Serval ID
serval:BIB_C9A6C6989696
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evaluation of prenatal diagnosis of congenital heart disease in a regional controlled case study.
Journal
Swiss Medical Weekly
Author(s)
Rossier M.C., Mivelaz Y., Addor M.C., Sekarski N., Meijboom E.J., Vial Y.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
144
Pages
w14068
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
AIMS: This study evaluated the evolution of the prenatal diagnosis of congenital heart disease (CHD) between 2003 and 2008 and its repercussion for the CHD prevalence rate at birth in a well-defined population (Canton of Vaud, Switzerland).
METHODS AND RESULTS: All 572 cases of CHD reported in the Eurocat Registry of Vaud-Switzerland between 1.5.2003 and 31.12.2008 were analysed and compared with the cases in our clinical database. CHD cases were divided into five different groups according to heart disease severity. The prenatal detection rates increased significantly between 2003 and 2008, with a mean detection rate of 25.2%. There was a significantly higher rate of prenatal diagnosis in the first four groups of CHD severity, with the highest detection rate (87.5%) found in the group with the most severe CHD (group 1). In this group, 85.7% of cases resulted in a termination of pregnancy, and there was a consequent 75% reduction in the prevalence of severe major cardiac malformation at birth. Detection rates were 66% in group 2, 68.6% in group 3, and the lowest in groups 4 and 5, with rates of 25.9% and 12.9%, respectively.
CONCLUSION: This study shows that the prenatal detection rate for CHD increased in a well-defined population over the study period. Prenatal diagnosis thus has had a major impact on patients with the most severe types of CHD and has resulted in a significant reduction in severe CHD at birth.
Pubmed
Web of science
Open Access
Yes
Create date
09/01/2015 20:06
Last modification date
20/08/2019 15:44
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