Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes.

Details

Ressource 1Download: 18950899_Postprint.pdf (1810.71 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_C578C03066C2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes.
Journal
Neurobiology of aging
Author(s)
Miklossy J., Qing H., Radenovic A., Kis A., Vileno B., Làszló F., Miller L., Martins R.N., Waeber G., Mooser V., Bosman F., Khalili K., Darbinian-Sarlissian N., McGeer P.L.
ISSN
1558-1497 ([electronic])
Publication state
Published
Issued date
2008
Pages
1503-15
Language
english
Notes
Publication types: JOURNAL ARTICLE -
Abstract
Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (Abeta) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabetes and 11 controls) were analyzed. APP and tau mRNAs were identified in human pancreas and in cultured insulinoma beta cells (INS-1) by RT-PCR. Prominent APP and tau bands were detected by Western blotting in pancreatic extracts. Aggregated Abeta, hyperphosphorylated tau, ubiquitin, apolipoprotein E, apolipoprotein(a), IB1/JIP-1 and JNK1 were detected in Langerhans islets in type 2 diabetic patients. Abeta was co-localized with amylin in islet amyloid deposits. In situ beta sheet formation of islet amyloid deposits was shown by infrared microspectroscopy (SIRMS). LPS increased APP in non-neuronal cells as well. We conclude that Abeta deposits and hyperphosphorylated tau are also associated with type 2 diabetes, highlighting common pathogenetic features in neurodegenerative disorders, including AD and type 2 diabetes and suggesting that Abeta deposits and hyperphosphorylated tau may also occur in other organs than the brain.
Pubmed
Web of science
Create date
16/12/2008 9:49
Last modification date
20/08/2019 15:41
Usage data