GAP-independent functions of DLC1 in metastasis.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_BCC4B8BC9438
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
GAP-independent functions of DLC1 in metastasis.
Journal
Cancer Metastasis Reviews
Author(s)
Barras D., Widmann C.
ISSN
1573-7233 (Electronic)
ISSN-L
0167-7659
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
33
Number
1
Pages
87-100
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
Metastases are responsible for most cancer-related deaths. One of the hallmarks of metastatic cells is increased motility and migration through extracellular matrixes. These processes rely on specific small GTPases, in particular those of the Rho family. Deleted in liver cancer-1 (DLC1) is a tumor suppressor that bears a RhoGAP activity. This protein is lost in most cancers, allowing malignant cells to proliferate and disseminate in a Rho-dependent manner. However, DLC1 is also a scaffold protein involved in alternative pathways leading to tumor and metastasis suppressor activities. Recently, substantial information has been gathered on these mechanisms and this review is aiming at describing the potential and known alternative GAP-independent mechanisms allowing DLC1 to impair migration, invasion, and metastasis formation.
Pubmed
Web of science
Open Access
Yes
Create date
23/05/2014 17:20
Last modification date
20/08/2019 15:30
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