aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.

Details

Ressource 1Download: 3088202_BIB_B21AFEA3420E.pdf (612.87 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-SA 4.0
Serval ID
serval:BIB_B21AFEA3420E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.
Journal
Journal of Experimental Medicine
Author(s)
Accolla R.S., Jotterand-Bellomo M., Scarpellino L., Maffei A., Carra G., Guardiola J.
ISSN
0022-1007
Publication state
Published
Issued date
1986
Volume
164
Number
1
Pages
369-374
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
RJ 2.2.5 is a human B cell line that has lost the capacity to express MHC class II genes. The human class II-positive phenotype is restored in somatic cell hybrids between RJ 2.2.5 and mouse spleen cells. By karyotype and molecular studies of an informative family of hybrids we have now shown that the reexpression of human class II gene products, as well as the maintenance of the mouse class II-positive phenotype, correlates with the presence of mouse chromosome 16. Thus, the existence on this mouse chromosome of a newly found locus, designated by us aIr-1, that determines a trans-acting activator function for class II gene expression, is established. Possible implications of this finding are discussed.
Keywords
Animals, Chromosome Mapping, Gene Expression Regulation, Genes, MHC Class II, HLA Antigens, HLA-DR Antigens, Histocompatibility Antigens Class II, Hybridomas, Karyotyping, Mice, Polyploidy
Pubmed
Web of science
Open Access
Yes
Create date
22/05/2009 8:44
Last modification date
20/08/2019 15:20
Usage data