Male-pattern baldness susceptibility locus at 20p11.

Richards, J.B.; Yuan, X.; Geller, F.; Waterworth, D.; Bataille, V.; Glass, D.; Song, K.; Waeber, G.; Vollenweider, P.; Aben, K.K.; Kiemeney, L.A.; Walters, B.; Soranzo, N.; Thorsteinsdottir, U.; Kong, A.; Rafnar, T.; Deloukas, P.; Sulem, P.; Stefansson, H.; Stefansson, K.; Spector, T.D.; Mooser, V.

doi:10.1038/ng.255

Male-pattern baldness susceptibility locus at 20p11.

Details

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Serval ID

serval:BIB_AFB4769B6AAE

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Male-pattern baldness susceptibility locus at 20p11.

Journal

Nature Genetics

Author(s)

Richards J.B., Yuan X., Geller F., Waterworth D., Bataille V., Glass D., Song K., Waeber G., Vollenweider P., Aben K.K., Kiemeney L.A., Walters B., Soranzo N., Thorsteinsdottir U., Kong A., Rafnar T., Deloukas P., Sulem P., Stefansson H., Stefansson K., Spector T.D., Mooser V.

ISSN

1546-1718

Publication state

Published

Issued date

2008

Peer-reviewed

Oui

Volume

Number

Pages

1282-1284

Language

english

Notes

Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish

Abstract

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

Keywords

Alopecia, Chromosomes, Human, Pair 20, Female, Genetic Predisposition to Disease, Genome, Human, Humans, Male, Polymorphism, Single Nucleotide

URN

urn:nbn:ch:serval-BIB_AFB4769B6AAE2

OAI-PMH

oai:serval.unil.ch:BIB_AFB4769B6AAE

DOI

10.1038/ng.255

Pubmed

18849991

Web of science

000260501500017