Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia.

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State: Public
Version: author
Serval ID
serval:BIB_8C089A0C707E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia.
Journal
Neuron
Author(s)
Cabungcal J.H., Counotte D.S., Lewis E.M., Tejeda H.A., Piantadosi P., Pollock C., Calhoon G.G., Sullivan E.M., Presgraves E., Kil J., Hong L.E., Cuenod M., Do K.Q., O'Donnell P.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
83
Number
5
Pages
1073-1084
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Abnormal development can lead to deficits in adult brain function, a trajectory likely underlying adolescent-onset psychiatric conditions such as schizophrenia. Developmental manipulations yielding adult deficits in rodents provide an opportunity to explore mechanisms involved in a delayed emergence of anomalies driven by developmental alterations. Here we assessed whether oxidative stress during presymptomatic stages causes adult anomalies in rats with a neonatal ventral hippocampal lesion, a developmental rodent model useful for schizophrenia research. Juvenile and adolescent treatment with the antioxidant N-acetyl cysteine prevented the reduction of prefrontal parvalbumin interneuron activity observed in this model, as well as electrophysiological and behavioral deficits relevant to schizophrenia. Adolescent treatment with the glutathione peroxidase mimic ebselen also reversed behavioral deficits in this animal model. These findings suggest that presymptomatic oxidative stress yields abnormal adult brain function in a developmentally compromised brain, and highlight redox modulation as a potential target for early intervention.
Pubmed
Web of science
Open Access
Yes
Create date
02/10/2014 17:24
Last modification date
20/08/2019 14:50
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