External radiotherapy and anaemia treatment: state of the art.

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State: Public
Version: author
Serval ID
serval:BIB_8BEEB0A26553
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
External radiotherapy and anaemia treatment: state of the art.
Journal
Swiss medical weekly
Author(s)
Ozsahin M., Azria D., Beer K., Mirimanoff R.O., Zouhair A.
ISSN
1424-7860 (Print)
ISSN-L
0036-7672
Publication state
Published
Issued date
08/01/2005
Peer-reviewed
Oui
Volume
135
Number
1-2
Pages
4-10
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Anaemia is considered a common problem in many cancers secondary to the disease itself or related to chemo- and/or radiotherapy. Several clinical trials have advocated the prognostic value of anaemia and hypoxia in the outcome of many cancers. Erythropoietin is recognised as an effective treatment for anaemia, which also improves the quality of life in patients with malignant disease. External radiotherapy plays an important role in the treatment of loco-regional cancer but its efficacy can be compromised by many factors. Tumor hypoxia is considered by many authors as an important factor contributing to radioresistance. We report in this article the radiobiological rationale in favour of combining radiotherapy and erythropoietin, and review relevant clinical papers published in this field.

Keywords
Anemia/drug therapy, Anemia/etiology, Clinical Trials as Topic, Combined Modality Therapy, Epoetin Alfa, Erythropoietin/therapeutic use, Hematinics/therapeutic use, Humans, Neoplasms/complications, Neoplasms/radiotherapy, Recombinant Proteins, Treatment Outcome
Pubmed
Web of science
Create date
24/01/2008 17:20
Last modification date
20/08/2019 14:50
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