Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes.

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Serval ID
serval:BIB_8A8475AEC7A1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
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Publications
Institution
Title
Positive and negative regulation of T cell responses by fibroblastic reticular cells within paracortical regions of lymph nodes.
Journal
Frontiers in Immunology
Author(s)
Siegert S., Luther S.A.
ISSN
1664-3224 (Electronic)
ISSN-L
1664-3224
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
3
Number
285
Pages
285
Language
english
Abstract
Fibroblastic reticular cells (FRC) form the structural backbone of the T cell rich zones in secondary lymphoid organs (SLO), but also actively influence the adaptive immune response. They provide a guidance path for immigrating T lymphocytes and dendritic cells (DC) and are the main local source of the cytokines CCL19, CCL21, and IL-7, all of which are thought to positively regulate T cell homeostasis and T cell interactions with DC. Recently, FRC in lymph nodes (LN) were also described to negatively regulate T cell responses in two distinct ways. During homeostasis they express and present a range of peripheral tissue antigens, thereby participating in peripheral tolerance induction of self-reactive CD8(+) T cells. During acute inflammation T cells responding to foreign antigens presented on DC very quickly release pro-inflammatory cytokines such as interferon γ. These cytokines are sensed by FRC which transiently produce nitric oxide (NO) gas dampening the proliferation of neighboring T cells in a non-cognate fashion. In summary, we propose a model in which FRC engage in a bidirectional crosstalk with both DC and T cells to increase the efficiency of the T cell response. However, during an acute response, FRC limit excessive expansion and inflammatory activity of antigen-specific T cells. This negative feedback loop may help to maintain tissue integrity and function during rapid organ growth.
Keywords
lymph node stromal cells, immune tolerance, suppression, mesenchymal stem cells, T lymphocyte activation, fibroblastic reticular cell (FRC), inducible nitric oxide synthase, cyclooxygenase 2
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2013 9:55
Last modification date
20/08/2019 14:49
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