Immune responses to airborne fungi and non-invasive airway diseases.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_8A4D897B60AF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immune responses to airborne fungi and non-invasive airway diseases.
Journal
Seminars in Immunopathology
Author(s)
Vacher Gaëlle, Niculita-Hirzel Hélène, Roger Thierry
ISSN
1863-2300 (Electronic)
ISSN-L
1863-2297
Publication state
Published
Issued date
2015
Volume
37
Number
2
Pages
83-96
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish Document type : review
Abstract
Inhalation of fungal particles is a ubiquitous way of exposure to microorganisms during human life; however, this exposure may promote or exacerbate respiratory diseases only in particular exposure conditions and human genetic background. Depending on the fungal species and form, fungal particles can induce symptoms in the lung by acting as irritants, aeroallergens or pathogens causing infection. Some thermophilic species can even act in all these three ways (e.g. Aspergillus, Penicillium), mesophilic species being only involved in allergic and/or non-allergic airway diseases (e.g. Cladosporium, Alternaria, Fusarium). The goal of the present review is to present the current knowledge on the interaction between airborne fungal particles and the host immune system, to illustrate the differences of immune sensing of different fungal species and to emphasise the importance of conducting research on non-conventional mesophilic fungal species. Indeed, the diversity of fungal species we inhale and the complexity of their composition have a direct impact on fungal particle recognition and immune system decision to tolerate or respond to those particles, eventually leading to collateral damages promoting airway pathologies.
Pubmed
Web of science
Open Access
Yes
Create date
13/03/2015 18:33
Last modification date
20/08/2019 14:49
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