Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye.

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State: Public
Version: Final published version
Serval ID
serval:BIB_867956295262
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye.
Journal
Investigative Ophthalmology and Visual Science
Author(s)
Behar-Cohen F.F., Goureau O., D'Hermies F., Courtois Y.
ISSN
0146-0404 (Print)
ISSN-L
0146-0404
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
37
Number
8
Pages
1711-1715
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
PURPOSE: To evaluate the effect of intraocular administration of nitric oxide (NO) donors in the rabbit eye on intraocular pressure (IOP), inflammation, and toxicity.
METHODS: Intravitreal and intracameral injections of two NO donors, SIN-1 and SNAP, and SIN-1C and BSS were performed. Clinical examination, IOP measurements, protein evaluation in aqueous humor, and histologic analysis of the ocular globes were realized. Nitric oxide release was demonstrated by nitrite production in the aqueous humor and in the vitreous using the Griess reaction.
RESULTS: The drastic decrease of IOP, observed after a single NO donor injection, was correlated directly with nitrite production and, thus, to NO release. Injection of inactive metabolite of SIN-1, SIN-1C, which is not able to release NO, did not modulate IOP. When administered in the aqueous humor or in the vitreous, NO did not diffuse from one segment of the eye to another. No inflammation or histologic damage was observed as a result of a single NO donor administration.
CONCLUSIONS: Nitric oxide is implicated directly in the regulation of IOP and its acute, and massive release into the rabbit eye did not induce inflammation or other growth toxic effects on the ocular tissues.
Keywords
Acetonitriles/pharmacology, Animals, Aqueous Humor/drug effects, Aqueous Humor/metabolism, Eye/metabolism, Eye Proteins/metabolism, Female, Injections, Intraocular Pressure/drug effects, Molsidomine/analogs & derivatives, Molsidomine/pharmacology, Morpholines/pharmacology, Nitric Oxide/pharmacology, Nitrites/metabolism, Ocular Hypotension/chemically induced, Penicillamine/analogs & derivatives, Penicillamine/pharmacology, Rabbits, S-Nitroso-N-Acetylpenicillamine, Vasodilator Agents/pharmacology, Vitreous Body/drug effects, Vitreous Body/metabolism
Pubmed
Web of science
Create date
10/04/2014 13:31
Last modification date
20/08/2019 14:45
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