How Are Sleep Characteristics Related to Cardiovascular Health? Results From the Population-Based HypnoLaus study.

Details

Ressource 1Download: 30898062.pdf (573.63 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Secondary document(s)
Download: 30898062AM.pdf (473.77 [Ko])
State: Public
Version: Author's accepted manuscript
License: Not specified
Download: 20190111Supplementary files.pdf (282.58 [Ko])
State: Public
Version: Supplementary document
License: Not specified
Serval ID
serval:BIB_7F72897907B9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
How Are Sleep Characteristics Related to Cardiovascular Health? Results From the Population-Based HypnoLaus study.
Journal
Journal of the American Heart Association
Author(s)
Häusler N., Marques-Vidal P., Heinzer R. (co-last), Haba-Rubio J. (co-last)
ISSN
2047-9980 (Electronic)
ISSN-L
2047-9980
Publication state
Published
Issued date
02/04/2019
Peer-reviewed
Oui
Volume
8
Number
7
Pages
e011372
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Background Although sleep characteristics have been linked to cardiovascular disease and cardiovascular risk factors, the association between sleep characteristics measured by polysomnography and cardiovascular health ( CVH ) remains unknown. Methods and Results In a population-based sample (n=1826), sleep characteristics were assessed by both sleep questionnaires and polysomnography. Global, behavioral, and biological CVH were defined according to the American Heart Association. Multinomial logistic regressions were performed to estimate relative risk ratios and 95% CI . Strong dose-response associations were found between all oxygen saturation-related variables (oxygen desaturation index, mean oxygen saturation, and percentage of total sleep time spent under 90% oxygen saturation) and obstructive sleep apnea (severity categories and apnea/hypopnea index) and global, behavioral, and biological CVH . Mean oxygen saturation had the strongest positive association (relative risk ratios 1.31 [ CI 1.22-1.41]; 1.78 [ CI 1.55-2.04] for intermediate relative to ideal CVH ), and oxygen desaturation index had the strongest negative association (relative risk ratios 0.71 [ CI 0.65-0.78]; 0.45 [ CI 0.34-0.58] for intermediate relative to ideal CVH ) with global CVH , and these associations were also the most robust in sensitivity analyses. The impacts of sleep architecture and sleep fragmentation were less consistent. Conclusions Mean oxygen saturation, oxygen desaturation index, and apnea/hypopnea index were associated with CVH . Conversely, most variables related to sleep architecture and sleep fragmentation were not consistently related to CVH . Sleep-disordered breathing and the associated oxygen (de)saturation were associated with CVH more strongly than with sleep fragmentation.
Keywords
Adult, Aged, Blood Glucose/metabolism, Blood Pressure, Body Mass Index, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/metabolism, Cholesterol/metabolism, Diet, Exercise, Female, Humans, Hypoxia/epidemiology, Hypoxia/metabolism, Logistic Models, Male, Middle Aged, Oxygen/metabolism, Polysomnography, Sleep, Sleep Apnea, Obstructive/epidemiology, Sleep Apnea, Obstructive/metabolism, Sleep Deprivation/epidemiology, Smoking/epidemiology, Switzerland/epidemiology, cardiovascular disease prevention, cardiovascular health, mean oxygen saturation, oxidative stress, oxygen desaturation index, polysomnography, sleep
Pubmed
Web of science
Open Access
Yes
Create date
25/03/2019 8:51
Last modification date
21/11/2022 8:23
Usage data