Transformation of a microprolactinoma into a mixed growth hormone and prolactin-secreting pituitary adenoma.

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Serval ID
serval:BIB_7D2FAB69D989
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Transformation of a microprolactinoma into a mixed growth hormone and prolactin-secreting pituitary adenoma.
Journal
Frontiers in Endocrinology
Author(s)
Dessimoz C., Browaeys P., Maeder P., Lhermitte B., Pitteloud N., Momjian S., Pralong F.P.
ISSN
1664-2392 (Electronic)
ISSN-L
1664-2392
Publication state
Published
Issued date
2011
Volume
2
Number
116
Pages
1-5
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Combined prolactin (PRL) and growth hormone (GH) secretion by a single pituitary tumor can occur in approximately 5% of cases. However, in all previously reported patients, combined secretion of both hormones was present at the time of diagnosis. Here we describe a patient initially diagnosed with a pure prolactin-secreting microadenoma, who experienced the progressive apparition of symptomatic autonomous GH secretion while on intermittent long term dopamine agonist therapy. She was operated on, and immunohistochemical analysis of tumor tissue confirmed the diagnosis of pituitary adenoma with uniform co-staining of all cells for both GH and PRL. This patient represents the first documented occurrence of asynchronous development of combined GH and PRL secretion in a pituitary adenoma. Although pathogenic mechanisms implicated remain largely speculative, it emphasizes the need for long term hormonal follow up of patients harboring prolactinomas.
Pubmed
Open Access
Yes
Create date
12/02/2013 14:03
Last modification date
20/08/2019 14:38
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