Human cardiospheres as a source of multipotent stem and progenitor cells.

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Version: author
Serval ID
serval:BIB_7B755E337E4C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Human cardiospheres as a source of multipotent stem and progenitor cells.
Journal
Stem Cells International
Author(s)
Barile L., Gherghiceanu M., Popescu L.M., Moccetti T., Vassalli G.
ISSN
1687-966X (Print)
Publication state
Published
Issued date
2013
Volume
2013
Pages
916837
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish Document Type: Review; PDF : Review Article
Abstract
Cardiospheres (CSs) are self-assembling multicellular clusters from the cellular outgrowth from cardiac explants cultured in nonadhesive substrates. They contain a core of primitive, proliferating cells, and an outer layer of mesenchymal/stromal cells and differentiating cells that express cardiomyocyte proteins and connexin 43. Because CSs contain both primitive cells and committed progenitors for the three major cell types present in the heart, that is, cardiomyocytes, endothelial cells, and smooth muscle cells, and because they are derived from percutaneous endomyocardial biopsies, they represent an attractive cell source for cardiac regeneration. In preclinical studies, CS-derived cells (CDCs) delivered to infarcted hearts resulted in improved cardiac function. CDCs have been tested safely in an initial phase-1 clinical trial in patients after myocardial infarction. Whether or not CDCs are superior to purified populations, for example, c-kit(+) cardiac stem cells, or to gene therapy approaches for cardiac regeneration remains to be evaluated.
Pubmed
Web of science
Open Access
Yes
Create date
20/09/2013 17:37
Last modification date
20/08/2019 14:37
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