Neural control of vascular reactions: impact of emotion and attention.

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State: Public
Version: Final published version
Serval ID
serval:BIB_7A813F66B2F6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neural control of vascular reactions: impact of emotion and attention.
Journal
Journal of Neuroscience
Author(s)
Okon-Singer H., Mehnert J., Hoyer J., Hellrung L., Schaare H.L., Dukart J., Villringer A.
ISSN
1529-2401 (Electronic)
ISSN-L
0270-6474
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
34
Number
12
Pages
4251-4259
Language
english
Notes
Publication types: Journal Article
Abstract
This study investigated the neural regions involved in blood pressure reactions to negative stimuli and their possible modulation by attention. Twenty-four healthy human subjects (11 females; age = 24.75 ± 2.49 years) participated in an affective perceptual load task that manipulated attention to negative/neutral distractor pictures. fMRI data were collected simultaneously with continuous recording of peripheral arterial blood pressure. A parametric modulation analysis examined the impact of attention and emotion on the relation between neural activation and blood pressure reactivity during the task. When attention was available for processing the distractor pictures, negative pictures resulted in behavioral interference, neural activation in brain regions previously related to emotion, a transient decrease of blood pressure, and a positive correlation between blood pressure response and activation in a network including prefrontal and parietal regions, the amygdala, caudate, and mid-brain. These effects were modulated by attention; behavioral and neural responses to highly negative distractor pictures (compared with neutral pictures) were smaller or diminished, as was the negative blood pressure response when the central task involved high perceptual load. Furthermore, comparing high and low load revealed enhanced activation in frontoparietal regions implicated in attention control. Our results fit theories emphasizing the role of attention in the control of behavioral and neural reactions to irrelevant emotional distracting information. Our findings furthermore extend the function of attention to the control of autonomous reactions associated with negative emotions by showing altered blood pressure reactions to emotional stimuli, the latter being of potential clinical relevance.
Pubmed
Web of science
Open Access
Yes
Create date
01/05/2014 18:00
Last modification date
20/08/2019 14:36
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