High one year mortality in adults with sickle cell disease and end-stage renal disease.

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Serval ID
serval:BIB_7848DDA3A92E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High one year mortality in adults with sickle cell disease and end-stage renal disease.
Journal
British Journal of Haematology
Author(s)
McClellan A.C., Luthi J.C., Lynch J.R., Soucie J.M., Kulkarni R., Guasch A., Huff E.D., Gilbertson D., McClellan W.M., Debaun M.R.
ISSN
1365-2141 (Electronic)
ISSN-L
0007-1048
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
159
Number
3
Pages
360-367
Language
english
Notes
Publication types: Journal Article
Abstract
Adequate pre-dialysis care reduces mortality among end-stage renal disease (ESRD) patients. We tested the hypothesis that individuals with ESRD due to sickle cell disease (SCD-ESRD) receiving pre-ESRD care have lower mortality compared to individuals without pre-ESRD care. We examined the association between mortality and pre-ESRD care in incident SCD-ESRD patients who started haemodialysis between 1 June, 2005 and 31 May, 2009 using data provided by the Centers for Medicare and Medicaid Services (CMS). SCD-ESRD was reported for 410 (0·1%) of 442 017 patients. One year after starting dialysis, 108 (26·3%) patients with incident ESRD attributed to SCD died; the hazard ratio (HR) for mortality among patients with SCD-ESRD compared to those without SCD as the primary cause of renal failure was 2·80 (95% confidence interval [CI] 2·31-3·38). Patients with SCD-ESRD receiving pre-dialysis nephrology care had a lower death rate than those with SCD-ESRD who did not receive pre-dialysis nephrology care (HR = 0·67, 95% CI 0·45-0·99). The one-year mortality rate following an ESRD diagnosis was almost three times higher in individuals with SCD when compared to those without SCD but with ESRD and could be attenuated by pre-dialysis nephrology care.
Pubmed
Web of science
Open Access
Yes
Create date
15/11/2012 18:21
Last modification date
20/08/2019 14:35
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