Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Okbay, A.; Baselmans, B.M.; De Neve, J.E.; Turley, P.; Nivard, M.G.; Fontana, M.A.; Meddens, S.F.; Linnér, R.K.; Rietveld, C.A.; Derringer, J.; Gratten, J.; Lee, J.J.; Liu, J.Z.; de Vlaming, R.; Ahluwalia, T.S.; Buchwald, J.; Cavadino, A.; Frazier-Wood, A.C.; Furlotte, N.A.; Garfield, V.; Geisel, M.H.; Gonzalez, J.R.; Haitjema, S.; Karlsson, R.; van der Laan, S.W.; Ladwig, K.H.; Lahti, J.; van der Lee, S.J.; Lind, P.A.; Liu, T.; Matteson, L.; Mihailov, E.; Miller, M.B.; Minica, C.C.; Nolte, I.M.; Mook-Kanamori, D.; van der Most, P.J.; Oldmeadow, C.; Qian, Y.; Raitakari, O.; Rawal, R.; Realo, A.; Rueedi, R.; Schmidt, B.; Smith, A.V.; Stergiakouli, E.; Tanaka, T.; Taylor, K.; Wedenoja, J.; Wellmann, J.; Westra, H.J.; Willems, S.M.; Zhao, W.; Amin, N.; Bakshi, A.; Boyle, P.A.; Cherney, S.; Cox, S.R.; Davies, G.; Davis, O.S.; Ding, J.; Direk, N.; Eibich, P.; Emeny, R.T.; Fatemifar, G.; Faul, J.D.; Ferrucci, L.; Forstner, A.; Gieger, C.; Gupta, R.; Harris, T.B.; Harris, J.M.; Holliday, E.G.; Hottenga, J.J.; De Jager, P.L.; Kaakinen, M.A.; Kajantie, E.; Karhunen, V.; Kolcic, I.; Kumari, M.; Launer, L.J.; Franke, L.; Li-Gao, R.; Koini, M.; Loukola, A.; Marques-Vidal, P.; Montgomery, G.W.; Mosing, M.A.; Paternoster, L.; Pattie, A.; Petrovic, K.E.; Pulkki-Råback, L.; Quaye, L.; Räikkönen, K.; Rudan, I.; Scott, R.J.; Smith, J.A.; Sutin, A.R.; Trzaskowski, M.; Vinkhuyzen, A.E.; Yu, L.; Zabaneh, D.; Attia, J.R.; Bennett, D.A.; Berger, K.; Bertram, L.; Boomsma, D.I.; Snieder, H.; Chang, S.C.; Cucca, F.; Deary, I.J.; van Duijn, C.M.; Eriksson, J.G.; Bültmann, U.; de Geus, E.J.; Groenen, P.J.; Gudnason, V.; Hansen, T.; Hartman, C.A.; Haworth, C.M.; Hayward, C.; Heath, A.C.; Hinds, D.A.; Hyppönen, E.; Iacono, W.G.; Järvelin, M.R.; Jöckel, K.H.; Kaprio, J.; Kardia, S.L.; Keltikangas-Järvinen, L.; Kraft, P.; Kubzansky, L.D.; Lehtimäki, T.; Magnusson, P.K.; Martin, N.G.; McGue, M.; Metspalu, A.; Mills, M.; de Mutsert, R.; Oldehinkel, A.J.; Pasterkamp, G.; Pedersen, N.L.; Plomin, R.; Polasek, O.; Power, C.; Rich, S.S.; Rosendaal, F.R.; den Ruijter, H.M.; Schlessinger, D.; Schmidt, H.; Svento, R.; Schmidt, R.; Alizadeh, B.Z.; Sørensen, T.I.; Spector, T.D.; Steptoe, A.; Terracciano, A.; Thurik, A.R.; Timpson, N.J.; Tiemeier, H.; Uitterlinden, A.G.; Vollenweider, P.; Wagner, G.G.; Weir, D.R.; Yang, J.; Conley, D.C.; Smith, G.D.; Hofman, A.; Johannesson, M.; Laibson, D.I.; Medland, S.E.; Meyer, M.N.; Pickrell, J.K.; Esko, T.; Krueger, R.F.; Beauchamp, J.P.; Koellinger, P.D.; Benjamin, D.J.; Bartels, M.; Cesarini, D.

doi:10.1038/ng.3552

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Details

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Serval ID

serval:BIB_749211F19289

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Journal

Nature genetics

Author(s)

Okbay A., Baselmans B.M., De Neve J.E., Turley P., Nivard M.G., Fontana M.A., Meddens S.F., Linnér R.K., Rietveld C.A., Derringer J., Gratten J., Lee J.J., Liu J.Z., de Vlaming R., Ahluwalia T.S., Buchwald J., Cavadino A., Frazier-Wood A.C., Furlotte N.A., Garfield V., Geisel M.H., Gonzalez J.R., Haitjema S., Karlsson R., van der Laan S.W., Ladwig K.H., Lahti J., van der Lee S.J., Lind P.A., Liu T., Matteson L., Mihailov E., Miller M.B., Minica C.C., Nolte I.M., Mook-Kanamori D., van der Most P.J., Oldmeadow C., Qian Y., Raitakari O., Rawal R., Realo A., Rueedi R., Schmidt B., Smith A.V., Stergiakouli E., Tanaka T., Taylor K., Wedenoja J., Wellmann J., Westra H.J., Willems S.M., Zhao W., Amin N., Bakshi A., Boyle P.A., Cherney S., Cox S.R., Davies G., Davis O.S., Ding J., Direk N., Eibich P., Emeny R.T., Fatemifar G., Faul J.D., Ferrucci L., Forstner A., Gieger C., Gupta R., Harris T.B., Harris J.M., Holliday E.G., Hottenga J.J., De Jager P.L., Kaakinen M.A., Kajantie E., Karhunen V., Kolcic I., Kumari M., Launer L.J., Franke L., Li-Gao R., Koini M., Loukola A., Marques-Vidal P., Montgomery G.W., Mosing M.A., Paternoster L., Pattie A., Petrovic K.E., Pulkki-Råback L., Quaye L., Räikkönen K., Rudan I., Scott R.J., Smith J.A., Sutin A.R., Trzaskowski M., Vinkhuyzen A.E., Yu L., Zabaneh D., Attia J.R., Bennett D.A., Berger K., Bertram L., Boomsma D.I., Snieder H., Chang S.C., Cucca F., Deary I.J., van Duijn C.M., Eriksson J.G., Bültmann U., de Geus E.J., Groenen P.J., Gudnason V., Hansen T., Hartman C.A., Haworth C.M., Hayward C., Heath A.C., Hinds D.A., Hyppönen E., Iacono W.G., Järvelin M.R., Jöckel K.H., Kaprio J., Kardia S.L., Keltikangas-Järvinen L., Kraft P., Kubzansky L.D., Lehtimäki T., Magnusson P.K., Martin N.G., McGue M., Metspalu A., Mills M., de Mutsert R., Oldehinkel A.J., Pasterkamp G., Pedersen N.L., Plomin R., Polasek O., Power C., Rich S.S., Rosendaal F.R., den Ruijter H.M., Schlessinger D., Schmidt H., Svento R., Schmidt R., Alizadeh B.Z., Sørensen T.I., Spector T.D., Steptoe A., Terracciano A., Thurik A.R., Timpson N.J., Tiemeier H., Uitterlinden A.G., Vollenweider P., Wagner G.G., Weir D.R., Yang J., Conley D.C., Smith G.D., Hofman A., Johannesson M., Laibson D.I., Medland S.E., Meyer M.N., Pickrell J.K., Esko T., Krueger R.F., Beauchamp J.P., Koellinger P.D., Benjamin D.J., Bartels M., Cesarini D.

Working group(s)

LifeLines Cohort Study

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

06/2016

Peer-reviewed

Oui

Volume

Number

Pages

624-633

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Keywords

Anxiety Disorders/genetics, Bayes Theorem, Depression/genetics, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide

URN

urn:nbn:ch:serval-BIB_749211F192891

OAI-PMH

oai:serval.unil.ch:BIB_749211F19289

DOI

10.1038/ng.3552

Pubmed

27089181

Web of science

000376744200009