Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

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State: Public
Version: Final published version
Serval ID
serval:BIB_734834187D90
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.
Journal
BMC medical genetics
Author(s)
Sikhayeva N., Iskakova A., Saigi-Morgui N., Zholdybaeva E., Eap C.B., Ramanculov E.
ISSN
1471-2350 (Electronic)
ISSN-L
1471-2350
Publication state
Published
Issued date
24/07/2017
Peer-reviewed
Oui
Volume
18
Number
1
Pages
76
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
We evaluated the associations between single nucleotide polymorphisms and different clinical parameters related to type 2 diabetes mellitus (T2DM), obesity risk, and metabolic syndrome (MS) in a Kazakh cohort.
A total of 1336 subjects, including 408 T2DM patients and 928 control subjects, were recruited from an outpatient clinic and genotyped for 32 polymorphisms previously associated with T2DM and obesity-related phenotypes in other ethnic groups. For association studies, the chi-squared test or Fisher's exact test for binomial variables were used. Logistic regression was conducted to explore associations between the studied SNPs and the risk of developing T2DM, obesity, and MS, after adjustments for age and sex.
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2). In addition, examination of general unmatched T2DM and control cohorts revealed significant associations between T2DM and SNPsrs1799883 (FABP2) and rs9939609 (FTO). Furthermore, polymorphisms in the FTO gene were associated with increased obesity risk, whereas polymorphisms in the FTO and FABP2 genes were also associated with the risk of developing MS in general unmatched cohorts.
We confirmed associations between polymorphisms within the SLC30A8, TSPAN8/LGR5, FABP2, and FTO genes and susceptibility to T2DM in a Kazakh cohort, and revealed significant associations with anthropometric and metabolic traits. In particular, FTO and FABP2 gene polymorphisms were significantly associated with susceptibility to MS and obesity in this cohort.

Keywords
Adolescent, Adult, Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics, Asian Continental Ancestry Group, Diabetes Mellitus, Type 2/genetics, Diabetes Mellitus, Type 2/pathology, Ethnic Groups, Fatty Acid-Binding Proteins/genetics, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Kazakhstan, Male, Metabolic Syndrome X/genetics, Metabolic Syndrome X/pathology, Middle Aged, Obesity/genetics, Obesity/pathology, Polymorphism, Single Nucleotide, Risk Factors, Genetic variants, Kazakh cohort, Metabolic syndrome, Obesity, Type 2 diabetes mellitus
Pubmed
Web of science
Open Access
Yes
Create date
08/08/2017 9:43
Last modification date
20/08/2019 14:31
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