Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients.
Details
Download: REF.pdf (97.93 [Ko])
State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_67277776B4D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients.
Journal
Annals of Oncology
ISSN
0923-7534
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
17
Number
4
Pages
578-583
Language
english
Abstract
BACKGROUND: Exclusive liver metastases occur in up to 40% of patients with uveal melanoma associated with a median survival of 2-7 months. Single agent response rates with commonly available chemotherapy are below 10%. We have investigated the use of fotemustine via direct intra-arterial hepatic (i.a.h.) administration in patients with uveal melanoma metastases. PATIENTS AND METHODS: A total of 101 patients from seven centers were treated with i.a.h. fotemustine, administered intra-arterially weekly for a 4-week induction period, and then as a maintenance treatment every 3 weeks until disease progression, unacceptable toxicity or patient refusal. RESULTS: A median of eight fotemustine infusions per patient were delivered (range 1-26). Catheter related complications occurred in 23% of patients; however, this required treatment discontinuation in only 10% of the patients. The overall response rate was 36% with a median overall survival of 15 months and a 2-year survival rate of 29%. LDH, time between diagnosis and treatment start and gender were significant predictors of survival. CONCLUSIONS: Locoregional treatment with fotemustine is well tolerated and seems to improve outcome of this poor prognosis patient population. Median survival rates are among the longest reported and one-third of the patients are still alive at 2 years.
Keywords
Adult, Aged, Antineoplastic Agents, Female, Humans, Injections, Intra-Arterial, Liver Neoplasms, Male, Melanoma, Middle Aged, Nitrosourea Compounds, Organophosphorus Compounds, Uveal Neoplasms
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 14:10
Last modification date
14/02/2022 8:55