Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application.

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Serval ID
serval:BIB_66CFA0303946
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application.
Journal
Expert Review of Neurotherapeutics
Author(s)
Vezzani A., Dingledine R., Rossetti A.O.
ISSN
1473-7175; 1744-8360 (Electronic)
ISSN-L
1473-7175
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
15
Number
9
Pages
1081-1092
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublishDocument Type: Review
Abstract
Status epilepticus (SE) is a life-threatening neurological emergency often refractory to available treatment options. It is a very heterogeneous condition in terms of clinical presentation and causes, which besides genetic, vascular and other structural causes also include CNS or severe systemic infections, sudden withdrawal from benzodiazepines or anticonvulsants and rare autoimmune etiologies. Treatment of SE is essentially based on expert opinions and antiepileptic drug treatment per se seems to have no major impact on prognosis. There is, therefore, urgent need of novel therapies that rely upon a better understanding of the basic mechanisms underlying this clinical condition. Accumulating evidence in animal models highlights that inflammation ensuing in the brain during SE may play a determinant role in ongoing seizures and their long-term detrimental consequences, independent of an infection or auto-immune cause; this evidence encourages reconsideration of the treatment flow in SE patients.
Pubmed
Web of science
Create date
28/08/2015 12:54
Last modification date
20/08/2019 14:22
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