GLI 2012 equations define few spirometric anomalies in the general population: the PneumoLaus study.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_669A140C3A9C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
GLI 2012 equations define few spirometric anomalies in the general population: the PneumoLaus study.
Journal
Respiratory research
Author(s)
Lenoir A., Fitting J.W., Marques-Vidal P.M., Vollenweider P., Nicod L.P.
ISSN
1465-993X (Electronic)
ISSN-L
1465-9921
Publication state
Published
Issued date
13/12/2018
Peer-reviewed
Oui
Volume
19
Number
1
Pages
250
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Reduced lung function predicts increased mortality, but its prevalence may vary depending on definition considered, use of bronchodilation and applied reference values. We aimed to assess lung function abnormalities in Lausanne, Switzerland, and their association with clinical history.
In a general population sample, spirometry was performed and bronchodilation applied if the ratio forced expiratory volume in 1 s (FEV1) / forced vital capacity (FVC) or the FVC was below the lower limit of normal (LLN) according to Global Lung Function Initiative 2012 references. Results for FEV1/FVC according to the LLN were compared to the 0.7 fixed ratio. Respiratory risk factors, symptoms and self-reported respiratory diagnoses were recorded through a questionnaire.
Out of the 3342 included subjects, 3.8% had chronic obstruction and 2.5% reversible obstruction when using the LLN; possible lung restriction alone was present in 1.8%, and associated with chronic obstruction in 0.4%. Ever smokers had a higher prevalence of abnormal spirometry, chronic obstruction and reversible obstruction; there was no difference with regard to possible restriction. Overall, chronic airway obstruction was found in 8.9% of current smokers, 4.6% of former smokers and 1.5% of never smokers. Only one third of participants with chronic obstruction were aware of a respiratory disease.
Prevalence of abnormal lung function in the population of Lausanne is low. This may be due to a low rate of ever-smokers, the application of a full bronchodilation dose, but also to inherent characteristics of this population.
Keywords
Aged, Cohort Studies, Female, Follow-Up Studies, Forced Expiratory Volume/physiology, Humans, Lung/physiology, Lung Diseases, Obstructive/diagnosis, Lung Diseases, Obstructive/epidemiology, Lung Diseases, Obstructive/physiopathology, Male, Middle Aged, Population Surveillance/methods, Prospective Studies, Reference Values, Spirometry/methods, Spirometry/standards, Switzerland/epidemiology, Tidal Volume/physiology, Vital Capacity, Airway obstruction, GLI 2012, Lung restriction, Population study, Smoking, Spirometry
Pubmed
Web of science
Open Access
Yes
Create date
03/01/2019 10:56
Last modification date
20/08/2019 14:22
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