The dynamic changes of dominant clones of Staphylococcus aureus causing bloodstream infections in the European region: results of a second structured survey.

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State: Public
Version: Final published version
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Serval ID
serval:BIB_65C6A3E34732
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The dynamic changes of dominant clones of Staphylococcus aureus causing bloodstream infections in the European region: results of a second structured survey.
Journal
Euro surveillance
Author(s)
Grundmann H., Schouls L.M., Aanensen D.M., Pluister G.N., Tami A., Chlebowicz M., Glasner C., Sabat A.J., Weist K., Heuer O., Friedrich A.W.
Working group(s)
ESCMID Study Group on Molecular Epidemiological Markers, European Staphylococcal Reference Laboratory Working Group
Contributor(s)
Denis O., Nashev D., Blanc D.S., Pieridou-Bagatzouni D., Jakubu V., Zemlickova H., Westh H., Larsen A.R., Skov R., Laurent F., Layer F., Witte W., Spiliopoulou I., Salmenlinna S., Lindholm L., Vuopio-Varkila J., Toth A., Ungvari E., Brennan G., Shore A., Miklasevics E., Balode A., Haraldsson G., Kristinsson K.G., Monaco M., Pantosti A., Borg M., Huijsdens X., Heck M., Marstein L., Jacobsen T., Gran F., Faria N., de Lencastre H., Empel J., Kozińska A., Hryniewicz W., Codita I., Perez-Vazquez M., Vindel A., Švent Kučina N., Haeggman S., Liljequist B.O., Pichon B., Kearns A., Edwards G.
ISSN
1560-7917 (Electronic)
ISSN-L
1025-496X
Publication state
Published
Issued date
11/12/2014
Peer-reviewed
Oui
Volume
19
Number
49
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Staphylococcus aureus is one of the most important human pathogens and meticillin-resistant S. aureus (MRSA) presents a major cause of healthcare- and community-acquired infections. This study investigated the spatial and temporal changes of S. aureus causing bacteraemia in Europe over a five-year interval and explored the possibility of integrating pathogen-based typing data with epidemiological and clinical information at a European level. Between January 2011 and July 2011, 350 laboratories serving 453 hospitals in 25 countries collected 3,753 isolates (meticillin-sensitive S. aureus (MSSA) and MRSA) from patients with S. aureus bloodstream infections. All isolates were sent to the national staphylococcal reference laboratories and characterised by quality-controlled spa typing. Data were uploaded to an interactive web-based mapping tool. A wide geographical distribution of spa types was found, with some prevalent in all European countries. MSSA was more diverse than MRSA. MRSA differed considerably between countries with major international clones expanding or receding when compared to a 2006 survey. We provide evidence that a network approach of decentralised typing and visualisation of aggregated data using an interactive mapping tool can provide important information on the dynamics of S. aureus populations such as early signalling of emerging strains, cross-border spread and importation by travel.
Keywords
Anti-Bacterial Agents/pharmacology, Bacterial Typing Techniques, Data Collection, Europe, Female, Genetic Variation, Genotype, Humans, Male, Methicillin-Resistant Staphylococcus aureus, Microbial Sensitivity Tests, Molecular Epidemiology, Multilocus Sequence Typing, Staphylococcal Infections/blood, Staphylococcal Infections/epidemiology, Staphylococcal Infections/microbiology, Staphylococcal Protein A/genetics, Staphylococcus aureus/classification, Staphylococcus aureus/drug effects, Staphylococcus aureus/genetics, Staphylococcus aureus/isolation & purification
Pubmed
Create date
08/11/2018 11:36
Last modification date
20/08/2019 14:21
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