Genetic variation in LIN28B is associated with the timing of puberty.

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Serval ID
serval:BIB_6025118E6981
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genetic variation in LIN28B is associated with the timing of puberty.
Journal
Nature Genetics
Author(s)
Ong K.K., Elks C.E., Li S., Zhao J.H., Luan J., Andersen L.B., Bingham S.A., Brage S., Smith G.D., Ekelund U., Gillson C.J., Glaser B., Golding J., Hardy R., Khaw K.T., Kuh D., Luben R., Marcus M., McGeehin M.A., Ness A.R., Northstone K., Ring S.M., Rubin C., Sims M.A., Song K., Strachan D.P., Vollenweider P., Waeber G., Waterworth D.M., Wong A., Deloukas P., Barroso I., Mooser V., Loos R.J., Wareham N.J.
ISSN
1546-1718[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
41
Number
6
Pages
729-733
Language
english
Abstract
The timing of puberty is highly variable. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 x 10(-8)). In independent replication studies in 16,373 women, each major allele was associated with 0.12 years earlier menarche (95% CI = 0.08-0.16; P = 2.8 x 10(-10); combined P = 3.6 x 10(-16)). This allele was also associated with earlier breast development in girls (P = 0.001; N = 4,271); earlier voice breaking (P = 0.006, N = 1,026) and more advanced pubic hair development in boys (P = 0.01; N = 4,588); a faster tempo of height growth in girls (P = 0.00008; N = 4,271) and boys (P = 0.03; N = 4,588); and shorter adult height in women (P = 3.6 x 10(-7); N = 17,274) and men (P = 0.006; N = 9,840) in keeping with earlier growth cessation. These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development.
Keywords
Colaus Study
Pubmed
Web of science
Open Access
Yes
Create date
05/06/2009 6:24
Last modification date
20/08/2019 14:17
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