Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder.
Details
Serval ID
serval:BIB_5FEDD55F2F56
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder.
Journal
Communications biology
Working group(s)
Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium
Contributor(s)
Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer TFM, Bacanu S.A., Bækvad-Hansen M., Beekman ATF, Bigdeli T.B., Binder E.B., Blackwood DHR, Bryois J., Buttenschøn H.N., Bybjerg-Grauholm J., Cai N., Castelao E., Christensen J.H., Clarke T.K., Coleman JRI, Colodro-Conde L., Couvy-Duchesne B., Craddock N., Crawford G.E., Davies G., Deary I.J., Degenhardt F., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Escott-Price V., Kiadeh FFH, Finucane H.K., Forstner A.J., Frank J., Gaspar H.A., Gill M., Goes F.S., Gordon S.D., Grove J., Hansen C.S., Hansen T.F., Herms S., Hickie I.B., Hoffmann P., Homuth G., Horn C., Hottenga J.J., Hougaard D.M., Ising M., Jansen R., Jones I., Jones L.A., Jorgenson E., Knowles J.A., Kohane I.S., Kraft J., Kretzschmar W.W., Krogh J., Kutalik Z., Li Y., Lind P.A., MacIntyre D.J., MacKinnon D.F., Maier R.M., Maier W., Marchini J., Mbarek H., McGrath P., McGuffin P., Medland S.E., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Milani L., Mondimore F.M., Montgomery G.W., Mostafavi S., Mullins N., Nauck M., Ng B., Nivard M.G., Nyholt D.R., Oskarsson H., Owen M.J., Painter J.N., Pedersen C.B., Pedersen M.G., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Posthuma D., Quiroz J.A., Qvist P., Rice J.P., Riley B.P., Rivera M., Mirza S.S., Schoevers R., Schulte E.C., Shen L., Shyn S.I., Sigurdsson E., Sinnamon GCB, Smit J.H., Smith D.J., Stefansson H., Steinberg S., Streit F., Strohmaier J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Traylor M., Treutlein J., Trubetskoy V., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Wang Y., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Witt S.H., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Baune B.T., Berger K., Boomsma D.I., Cichon S., Dannlowski U., de Geus EJC, DePaulo J.R., Domenici E., Domschke K., Esko T., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Kendler K.S., Kloiber S., Lewis G., Li Q.S., Lucae S., Madden PAF, Magnusson P.K., Martin N.G., McIntosh A.M., Metspalu A., Mors O., Mortensen P.B., Müller-Myhsok B., Nordentoft M., Nöthen M.M., O'Donovan M.C., Paciga S.A., Pedersen N.L., Penninx BWJH, Perlis R.H., Porteous D.J., Potash J.B., Preisig M., Rietschel M., Schaefer C., Schulze T.G., Smoller J.W., Stefansson K., Tiemeier H., Uher R., Völzke H., Weissman M.M., Werge T., Lewis C.M., Levinson D.F., Børglum A.D., Sullivan P.F., Meier S., Strauss J., Xu W., Vincent J.B., Matthews K., Ferreira M., O'Dushlaine C., Purcell S., Raychaudhuri S., Ruderfer D.M., Sklar P., Scott L.J., Flickinger M., Burmeister M., Li J., Guan W., Absher D., Thompson R.C., Meng F.G., Schatzberg A.F., Bunney W.E., Barchas J.D., Watson S.J., Myers R.M., Akil H., Boehnke M., Chambert K., Moran J., Scolnick E., Djurovic S., Melle I., Morken G., Corvin A., Anjorin A., Kandaswamy R., Lawrence J., McLean A.W., Pickard B.S., Bergen S.E., Nimgaonkar V., Landén M., Schalling M., Osby U., Backlund L., Frisén L., Langstrom N., Stahl E., Dobbyn A., Jamain S., Etain B., Bellivier F., Leber M., Maaser A., Fischer S.B., Reinbold C.S., Kittel-Schneider S., Fullerton J.M., Oruč L., Para J.G., Mayoral F., Rivas F., Czerski P.M., Kammerer-Ciernioch J., Vedder H., Borrmann-Hassenbach M., Pfennig A., Brennan P., McKay J.D., Kogevinas M., Schwarz M., Schofield P.R., Mühleisen T.W., Schumacher J., Bauer M., Wright A., Mitchell P.B., Hautzinger M., Kelsoe J.R., Greenwood T.A., Nievergelt C.M., Shilling P.D., Smith E.N., Bloss C.S., Edenberg H.J., Koller D.L., Gershon E.S., Liu C., Badner J.A., Scheftner W.A., Lawson W.B., Nwulia E.A., Hipolito M., Coryell W., Rice J., Byerley W., McMahon F.J., Lohoff F.W., Zandi P.P., Mahon P.B., McInnis M.G., Zöllner S., Zhang P., Szelinger S., St Clair D., Caesar S., Gordon-Smith K., Fraser C., Green E.K., Grozeva D., Hamshere M.L., Kirov G., Nikolov I., Collier D.A., Elkin A., Williamson R., Young A.H., Ferrier I.N., Milanova V., Alda M., Cervantes P., Cruceanu C., Rouleau G.A., Turecki G., Paciga S., Winslow A.R., Grigoroiu-Serbanescu M., Ophoff R., Adolfsson R., Adolfsson A.N., Del-Favero J., Pato C., Biernacka J.M., Frye M.A., Morris D., Schork N.J., Reif A., Lissowska J., Hauser J., Szeszenia-Dabrowska N., McGhee K., Quinn E., Moskvina V., Holmans P.A., Farmer A., Kennedy J.L., Andreassen O.A., Mattingsdal M., Gill M., Bass N.J., Gurling H., McQuillin A., Breuer R., Hultman C., Lichtenstein P., Huckins L.M., Leboyer M., Lathrop M., Nurnberger J., Steffens M., Foroud T.M., Berrettini W.H., Craig D.W., Shi J.
ISSN
2399-3642 (Electronic)
ISSN-L
2399-3642
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
1
Pages
163
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders.
Pubmed
Web of science
Open Access
Yes
Create date
28/03/2019 10:23
Last modification date
20/08/2019 15:17
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