Genome-wide association study identifies 74 loci associated with educational attainment.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_5E497C4331E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide association study identifies 74 loci associated with educational attainment.
Journal
Nature
Author(s)
Okbay A., Beauchamp J.P., Fontana M.A., Lee J.J., Pers T.H., Rietveld C.A., Turley P., Chen G.B., Emilsson V., Meddens S.F., Oskarsson S., Pickrell J.K., Thom K., Timshel P., de Vlaming R., Abdellaoui A., Ahluwalia T.S., Bacelis J., Baumbach C., Bjornsdottir G., Brandsma J.H., Pina Concas M., Derringer J., Furlotte N.A., Galesloot T.E., Girotto G., Gupta R., Hall L.M., Harris S.E., Hofer E., Horikoshi M., Huffman J.E., Kaasik K., Kalafati I.P., Karlsson R., Kong A., Lahti J., van der Lee S.J., deLeeuw C., Lind P.A., Lindgren K.O., Liu T., Mangino M., Marten J., Mihailov E., Miller M.B., van der Most P.J., Oldmeadow C., Payton A., Pervjakova N., Peyrot W.J., Qian Y., Raitakari O., Rueedi R., Salvi E., Schmidt B., Schraut K.E., Shi J., Smith A.V., Poot R.A., St Pourcain B., Teumer A., Thorleifsson G., Verweij N., Vuckovic D., Wellmann J., Westra H.J., Yang J., Zhao W., Zhu Z., Alizadeh B.Z., Amin N., Bakshi A., Baumeister S.E., Biino G., Bønnelykke K., Boyle P.A., Campbell H., Cappuccio F.P., Davies G., De Neve J.E., Deloukas P., Demuth I., Ding J., Eibich P., Eisele L., Eklund N., Evans D.M., Faul J.D., Feitosa M.F., Forstner A.J., Gandin I., Gunnarsson B., Halldórsson B.V., Harris T.B., Heath A.C., Hocking L.J., Holliday E.G., Homuth G., Horan M.A., Hottenga J.J., de Jager P.L., Joshi P.K., Jugessur A., Kaakinen M.A., Kähönen M., Kanoni S., Keltigangas-Järvinen L., Kiemeney L.A., Kolcic I., Koskinen S., Kraja A.T., Kroh M., Kutalik Z., Latvala A., Launer L.J., Lebreton M.P., Levinson D.F., Lichtenstein P., Lichtner P., Liewald D.C., Loukola A., Loukola A., Madden P.A., Mägi R., Mäki-Opas T., Marioni R.E., Marques-Vidal P., Meddens G.A., McMahon G., Meisinger C., Meitinger T., Milaneschi Y., Milani L., Montgomery G.W., Myhre R., Nelson C.P., Nyholt D.R., Ollier W.E., Palotie A., Paternoster L., Pedersen N.L., Petrovic K.E., Porteous D.J., Räikkönen K., Ring S.M., Robino A., Rostapshova O., Rudan I., Rustichini A., Salomaa V., Sanders A.R., Sarin A.P., Schmidt H., Scott R.J., Smith B.H., Smith J.A., Staessen J.A., Steinhagen-Thiessen E., Strauch K., Terracciano A., Tobin M.D., Ulivi S., Vaccargiu S., Quaye L., van Rooij F.J., Venturini C., Vinkhuyzen A.A., Völker U., Völzke H., Vonk J.M., Vozzi D., Waage J., Ware E.B., Willemsen G., Attia J.R., Bennett D.A., Berger K., Bertram L., Bisgaard H., Boomsma D.I., Borecki I.B., Bültmann U., Chabris C.F., Cucca F., Cusi D., Deary I.J., Dedoussis G.V., van Duijn C.M., Eriksson J.G., Franke B., Franke L., Gasparini P., Gejman P.V., Gieger C., Grabe H.J., Gratten J., Groenen P.J., Gudnason V., van der Harst P., Hayward C., Hinds D.A., Hoffmann W., Hyppönen E., Iacono W.G., Jacobsson B., Järvelin M.R., Jöckel K.H., Kaprio J., Kardia S.L., Lehtimäki T., Lehrer S.F., Magnusson P.K., Martin N.G., McGue M., Metspalu A., Pendleton N., Penninx B.W., Perola M., Pirastu N., Pirastu M., Polasek O., Posthuma D., Power C., Province M.A., Samani N.J., Schlessinger D., Schmidt R., Sørensen T.I., Spector T.D., Stefansson K., Thorsteinsdottir U., Thurik A.R., Timpson N.J., Tiemeier H., Tung J.Y., Uitterlinden A.G., Vitart V., Vollenweider P., Weir D.R., Wilson J.F., Wright A.F., Conley D.C., Krueger R.F., Davey Smith G., Hofman A., Laibson D.I., Medland S.E., Meyer M.N., Yang J., Johannesson M., Visscher P.M., Esko T., Koellinger P.D., Cesarini D., Benjamin D.J.
Working group(s)
LifeLines Cohort Study
Contributor(s)
Alizadeh BZ., de Boer RA., Boezen HM., Bruinenberg M., Franke L., van der Harst P., Hillege HL., van der Klauw MM., Navis G., Ormel J., Postma DS., Rosmalen JG., Slaets JP., Snieder H., Stolk RP., Wolffenbuttel BH., Wijmenga C.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
533
Number
7604
Pages
539-542
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Abstract
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Keywords
Alzheimer Disease/genetics, Bipolar Disorder/genetics, Brain/metabolism, Cognition, Computational Biology, Educational Status, Fetus/metabolism, Gene Expression Regulation/genetics, Gene-Environment Interaction, Genome-Wide Association Study, Great Britain, Humans, Molecular Sequence Annotation, Polymorphism, Single Nucleotide/genetics, Schizophrenia/genetics
Pubmed
Create date
24/06/2016 10:19
Last modification date
20/08/2019 14:16
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