Auditory-visual multisensory interactions in humans: timing, topography, directionality, and sources.

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Version: Final published version
Serval ID
serval:BIB_5E455DFE9FF3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Auditory-visual multisensory interactions in humans: timing, topography, directionality, and sources.
Journal
Journal of Neuroscience
Author(s)
Cappe C., Thut G., Romei V., Murray M.M.
ISSN
1529-2401[electronic], 0270-6474[linking]
Publication state
Published
Issued date
2010
Volume
30
Number
38
Pages
12572-12580
Language
english
Abstract
Current models of brain organization include multisensory interactions at early processing stages and within low-level, including primary, cortices. Embracing this model with regard to auditory-visual (AV) interactions in humans remains problematic. Controversy surrounds the application of an additive model to the analysis of event-related potentials (ERPs), and conventional ERP analysis methods have yielded discordant latencies of effects and permitted limited neurophysiologic interpretability. While hemodynamic imaging and transcranial magnetic stimulation studies provide general support for the above model, the precise timing, superadditive/subadditive directionality, topographic stability, and sources remain unresolved. We recorded ERPs in humans to attended, but task-irrelevant stimuli that did not require an overt motor response, thereby circumventing paradigmatic caveats. We applied novel ERP signal analysis methods to provide details concerning the likely bases of AV interactions. First, nonlinear interactions occur at 60-95 ms after stimulus and are the consequence of topographic, rather than pure strength, modulations in the ERP. AV stimuli engage distinct configurations of intracranial generators, rather than simply modulating the amplitude of unisensory responses. Second, source estimations (and statistical analyses thereof) identified primary visual, primary auditory, and posterior superior temporal regions as mediating these effects. Finally, scalar values of current densities in all of these regions exhibited functionally coupled, subadditive nonlinear effects, a pattern increasingly consistent with the mounting evidence in nonhuman primates. In these ways, we demonstrate how neurophysiologic bases of multisensory interactions can be noninvasively identified in humans, allowing for a synthesis across imaging methods on the one hand and species on the other.
Keywords
Acoustic Stimulation, Adolescent, Adult, Auditory Perception/physiology, Brain/physiology, Brain Mapping, Electroencephalography, Evoked Potentials/physiology, Female, Humans, Male, Nerve Net/physiology, Photic Stimulation, Signal Processing, Computer-Assisted, Visual Perception/physiology
Pubmed
Web of science
Open Access
Yes
Create date
20/01/2011 14:41
Last modification date
20/08/2019 14:16
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