The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates

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Serval ID
serval:BIB_5E049340248B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates
Journal
Genes and Immunity
Author(s)
Ortiz M., Kaessmann H., Zhang K., Bashirova A., Carrington M., Quintana-Murci L., Telenti A.
ISSN
1476-5470
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
9
Number
6
Pages
483-492
Language
english
Abstract
The CD209 gene family that encodes C-type lectins in primates includes CD209 (DC-SIGN), CD209L (L-SIGN) and CD209L2. Understanding the evolution of these genes can help understand the duplication events generating this family, the process leading to the repeated neck region and identify protein domains under selective pressure. We compiled sequences from 14 primates representing 40 million years of evolution and from three non-primate mammal species. Phylogenetic analyses used Bayesian inference, and nucleotide substitutional patterns were assessed by codon-based maximum likelihood. Analyses suggest that CD209 genes emerged from a first duplication event in the common ancestor of anthropoids, yielding CD209L2 and an ancestral CD209 gene, which, in turn, duplicated in the common Old World primate ancestor, giving rise to CD209L and CD209. K(A)/K(S) values averaged over the entire tree were 0.43 (CD209), 0.52 (CD209L) and 0.35 (CD209L2), consistent with overall signatures of purifying selection. We also assessed the Toll-like receptor (TLR) gene family, which shares with CD209 genes a common profile of evolutionary constraint. The general feature of purifying selection of CD209 genes, despite an apparent redundancy (gene absence and gene loss), may reflect the need to faithfully recognize a multiplicity of pathogen motifs, commensals and a number of self-antigens
Keywords
Amino Acid Sequence, Animals, Cell Adhesion, Cell Adhesion Molecules, chemistry, Evolution,Molecular, genetics, history, Humans, Lectins,C-Type, Mammals, microbiology, Models,Molecular, Molecular Sequence Data, Primates, Protein Structure,Tertiary, Receptors,Cell Surface, Switzerland
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 22:12
Last modification date
20/08/2019 14:16
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