Glial cells and chronic pain.

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Serval ID
serval:BIB_592AB714BC83
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Glial cells and chronic pain.
Journal
Neuroscientist
Author(s)
Gosselin R.D., Suter M.R., Ji R.R., Decosterd I.
ISSN
1089-4098[electronic], 1073-8584[linking]
Publication state
Published
Issued date
10/2010
Peer-reviewed
Oui
Volume
16
Number
5
Pages
519-531
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Abstract
Over the past few years, the control of pain exerted by glial cells has emerged as a promising target against pathological pain. Indeed, changes in glial phenotypes have been reported throughout the entire nociceptive pathway, from peripheral nerves to higher integrative brain regions, and pharmacological inhibition of such glial reactions reduces the manifestation of pain in animal models. This complex interplay between glia and neurons relies on various mechanisms depending both on glial cell types considered (astrocytes, microglia, satellite cells, or Schwann cells), the anatomical location of the regulatory process (peripheral nerve, spinal cord, or brain), and the nature of the chronic pain paradigm. Intracellularly, recent advances have pointed to the activation of specific cascades, such as mitogen-associated protein kinases (MAPKs) in the underlying processes behind glial activation. In addition, given the large number of functions accomplished by glial cells, various mechanisms might sensitize nociceptive neurons including a release of pronociceptive cytokines and neurotrophins or changes in neurotransmitter-scavenging capacity. The authors review the conceptual advances made in the recent years about the implication of central and peripheral glia in animal models of chronic pain and discuss the possibility to translate it into human therapies in the future.
Keywords
Animals, Chronic Disease, Humans, Neuroglia/metabolism, Nociceptors/metabolism, Pain/physiopathology, Synaptic Transmission/physiology
Pubmed
Web of science
Create date
19/10/2010 7:08
Last modification date
20/08/2019 14:12
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