Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty.

Details

Ressource 1Download: 26000306_BIB_53A767909B78.pdf (950.65 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_53A767909B78
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty.
Journal
BioMed Research International
Author(s)
Halfon M., Phan O., Teta D.
ISSN
2314-6141 (Electronic)
ISSN-L
2314-6133
Publication state
Published
Issued date
2015
Volume
2015
Pages
953241
Language
english
Abstract
Vitamin D is the main hormone of bone metabolism. However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. Hypovitaminosis D is consistently associated with decrease in muscle function and performance and increase in disability. On the contrary, vitamin D supplementation has been shown to improve muscle strength and gait in different settings, especially in elderly patients. Despite some controversies in the interpretation of meta-analysis, a reduced risk of falls has been attributed to vitamin D supplementation due to direct effects on muscle cells. Finally, a low vitamin D status is consistently associated with the frail phenotype. This is why many authorities recommend vitamin D supplementation in the frail patient.
Pubmed
Web of science
Open Access
Yes
Create date
22/07/2015 13:35
Last modification date
20/08/2019 14:08
Usage data