Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system.

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Ressource 1Download: 5_27559630_LPostprint.pdf (6172.75 [Ko])
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_4FEACB6E2C2A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system.
Journal
Current opinion in virology
Author(s)
Blessing D., Déglon N.
ISSN
1879-6265 (Electronic)
ISSN-L
1879-6257
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
21
Pages
61-66
Language
english
Notes
Publication types: Review ; Journal Article
Publication Status: ppublish
Abstract
The last two decades have witnessed the increasing instrumentalization of viruses, which have progressively evolved into highly potent gene transfer vehicles for a wide spectrum of applications. In the context of the central nervous system (CNS), their unique gene delivery features and targeting specificities have been exploited not only to improve our understanding of basic neurobiology, but also to investigate diseases or deliver therapeutic candidates. As a result, we have started moving away from the opportunistic use of recombinant vectors that are derived from naturally existing viruses toward the rational engineering of tailored lentivirus (LV) and adeno-associated virus (AAV) vectors for specific use in the CNS.

Pubmed
Web of science
Open Access
Yes
Create date
16/09/2016 19:33
Last modification date
20/08/2019 14:05
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