Addiction and arousal: the hypocretin connection

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Serval ID
serval:BIB_4EC91A702912
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Addiction and arousal: the hypocretin connection
Journal
Physiology and Behavior
Author(s)
Boutrel B., de Lecea L.
ISSN
0031-9384
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
93
Number
4-5
Pages
947-951
Language
english
Abstract
The hypocretins, also known as orexins, are two neuropeptides now commonly described as critical components to maintain and regulate the stability of arousal. Several lines of evidence have raised the hypothesis that hypocretin-producing neurons are part of the circuitries that mediate the hypothalamic response to acute stress. Intracerebral administration of hypocretin leads to a dose-related reinstatement of drug and food seeking behaviors. Furthermore, stress-induced reinstatement can be blocked with hypocretin receptor 1 antagonism. These results, together with recent data showing that hypocretin is critically involved in cocaine sensitization through the recruitment of NMDA receptors in the ventral tegmental area, strongly suggest that activation of hypocretin neurons play a critical role in the development of the addiction process. The activity of hypocretin neurons may affect addictive behavior by contributing to brain sensitization or by modulating the brain reward system. Hypocretinergic cells, in coordination with brain stress systems may lead to a vulnerable state that facilitates the resumption of drug seeking behavior. Hence, the hypocretinergic system is a new drug target that may be used to prevent relapse of drug seeking
Keywords
adverse effects, Affect, Animals, Arousal, Behavior,Addictive, Brain, chemically induced, Cocaine, drug effects, Humans, Intracellular Signaling Peptides and Proteins, Neuropeptides, Neurosciences, Peptides, pharmacology, physiology, Proteins, Psychiatry, Reward, Role, Switzerland
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 22:13
Last modification date
20/08/2019 14:04
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