The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy

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State: Public
Version: Final published version
Serval ID
serval:BIB_4919F894EBD8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy
Journal
Epilepsy Research and Treatment
Author(s)
Lucchese G., Spinosa J.P., Kanduc D.
ISSN
2090-1348 (Print)
2090-1356 (Electronic)
ISSN-L
2090-1348
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
2014
Pages
236309
Language
english
Notes
Publication types: Research Article ; research-article Identifiant PubMed Central: PMC4058587
Abstract
Sequence matching analyses show that Clostridium tetani neurotoxin shares numerous pentapeptides (68, including multiple occurrences) with 42 human proteins that, when altered, have been associated with epilepsy. Such a peptide sharing is higher than expected, nonstochastic, and involves tetanus toxin-derived epitopes that have been validated as immunopositive in the human host. Of note, an unexpected high level of peptide matching is found in mitogen-activated protein kinase 10 (MK10), a protein selectively expressed in hippocampal areas. On the whole, the data indicate a potential for cross-reactivity between the neurotoxin and specific epilepsy-associated proteins and may help evaluate the potential risk for epilepsy following immune responses induced by tetanus infection. Moreover, this study may contribute to clarifying the etiopathogenesis of the different types of epilepsy.
Pubmed
Open Access
Yes
Create date
11/07/2016 10:04
Last modification date
20/08/2019 13:56
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