Risk factors for the development of Fistulae and Stenoses in Crohn Disease patients in the Swiss Inflammatory Bowel Disease Cohort

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Version: Author's accepted manuscript
Serval ID
serval:BIB_45DC0ECE295B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Risk factors for the development of Fistulae and Stenoses in Crohn Disease patients in the Swiss Inflammatory Bowel Disease Cohort
Journal
Inflammatory Intestinal Diseases
Author(s)
Zeitz Jonas, Fournier Nicolas, Labenz Christian, Biedermann Luc, Frei Pascal, Misselwitz Benjamin, Scharl Sylvie, Vavricka Stephan R., Sulz Michael C., Fried Michael, Rogler Gerhard, Scharl Michael
ISSN
2296-9403
2296-9365
Publication state
Published
Issued date
2017
Volume
1
Number
4
Pages
172-181
Language
english
Abstract
Background: Fistulae and stenoses represent frequent and severe complications in patients with Crohn disease (CD). Our study aimed to identify risk factors for fistula and stenosis formation in CD patients. Summary: We retrieved data of 1,600 CD patients from the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). The risk for fistulae and stenoses in relation to gender, age at diagnosis, smoking status at diagnosis, and ileal involvement at diagnosis were analyzed. In the multivariate analysis, female gender showed a lower risk for developing perianal and any fistula (risk ratio [RR] 0.721, 95% confidence interval [CI] 0.582-0.893, p = 0.003 and RR 0.717, 95% CI 0.580-0.888, p = 0.002, respectively), and older age at diagnosis showed a lower risk for developing perianal fistula (RR 0.661, 95% CI 0.439-0.995, p = 0.047). Furthermore, ileal involvement was associated with a lower risk for perianal fistula (RR 0.713, 95% CI 0.561-0.906, p = 0.006), a lower risk for any fistula (RR 0.709, 95% CI 0.558-0.901, p = 0.005), and a higher risk for stenosis (RR 2.170, 95% CI 1.728-2.725, p < 0.001). Key Messages: In the nationwide SIBDCS, younger age at diagnosis and male gender were risk factors for developing perianal and nonperianal fistulae. Additionally, ileal involvement was revealed to be a potent risk factor (RR 2.170) for developing a stenosis.
Create date
18/07/2017 11:12
Last modification date
20/08/2019 13:50
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