Targeting cancer cell metabolism in pancreatic adenocarcinoma.

Details

Ressource 1Download: 26164081_BIB_3FE518F2703B.pdf (2595.93 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_3FE518F2703B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Targeting cancer cell metabolism in pancreatic adenocarcinoma.
Journal
Oncotarget
Author(s)
Cohen R., Neuzillet C., Tijeras-Raballand A., Faivre S., de Gramont A., Raymond E.
ISSN
1949-2553 (Electronic)
ISSN-L
1949-2553
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
6
Number
19
Pages
16832-16847
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer death by 2030. Current therapeutic options are limited, warranting an urgent need to explore innovative treatment strategies. Due to specific microenvironment constraints including an extensive desmoplastic stroma reaction, PDAC faces major metabolic challenges, principally hypoxia and nutrient deprivation. Their connection with oncogenic alterations such as KRAS mutations has brought metabolic reprogramming to the forefront of PDAC therapeutic research. The Warburg effect, glutamine addiction, and autophagy stand as the most important adaptive metabolic mechanisms of cancer cells themselves, however metabolic reprogramming is also an important feature of the tumor microenvironment, having a major impact on epigenetic reprogramming and tumor cell interactions with its complex stroma. We present a comprehensive overview of the main metabolic adaptations contributing to PDAC development and progression. A review of current and future therapies targeting this range of metabolic pathways is provided.
Keywords
Animals, Carcinoma, Pancreatic Ductal/metabolism, Carcinoma, Pancreatic Ductal/pathology, Disease Progression, Humans, Pancreatic Neoplasms/metabolism, Pancreatic Neoplasms/pathology
Pubmed
Web of science
Open Access
Yes
Create date
28/08/2015 17:42
Last modification date
20/08/2019 13:37
Usage data